Burden of severe 2009 pandemic influenza A (H1N1) infection in children in Southeast Spain.
Identifieur interne : 000362 ( Main/Exploration ); précédent : 000361; suivant : 000363Burden of severe 2009 pandemic influenza A (H1N1) infection in children in Southeast Spain.
Auteurs : Luis Moral [Espagne] ; Nuria Marco ; Teresa Toral ; María Jesús Fuentes ; Laura Fuentes ; Lucía LilloSource :
- Enfermedades infecciosas y microbiologia clinica [ 1578-1852 ]
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Antibactériens (usage thérapeutique), Antiviraux (usage thérapeutique), Association thérapeutique (MeSH), Comorbidité (MeSH), Enfant (MeSH), Enfant d'âge préscolaire (MeSH), Espagne (épidémiologie), Facteurs de risque (MeSH), Femelle (MeSH), Grippe humaine (thérapie), Grippe humaine (traitement médicamenteux), Grippe humaine (épidémiologie), Hospitalisation (statistiques et données numériques), Humains (MeSH), Mâle (MeSH), Nourrisson (MeSH), Nouveau-né (MeSH), Oséltamivir (usage thérapeutique), Oxygénothérapie (statistiques et données numériques), Pandémies (MeSH), Saisons (MeSH), Soins de réanimation (statistiques et données numériques), Sous-type H1N1 du virus de la grippe A (MeSH), Âge de début (MeSH).
- MESH :
- statistiques et données numériques : Hospitalisation, Oxygénothérapie, Soins de réanimation.
- thérapie : Grippe humaine.
- traitement médicamenteux : Grippe humaine.
- usage thérapeutique : Antibactériens, Antiviraux, Oséltamivir.
- épidémiologie : Espagne, Grippe humaine.
- Adolescent, Association thérapeutique, Comorbidité, Enfant, Enfant d'âge préscolaire, Facteurs de risque, Femelle, Humains, Mâle, Nourrisson, Nouveau-né, Pandémies, Saisons, Sous-type H1N1 du virus de la grippe A, Âge de début.
English descriptors
- KwdEn :
- Adolescent (MeSH), Age of Onset (MeSH), Anti-Bacterial Agents (therapeutic use), Antiviral Agents (therapeutic use), Child (MeSH), Child, Preschool (MeSH), Combined Modality Therapy (MeSH), Comorbidity (MeSH), Critical Care (statistics & numerical data), Female (MeSH), Hospitalization (statistics & numerical data), Humans (MeSH), Infant (MeSH), Infant, Newborn (MeSH), Influenza A Virus, H1N1 Subtype (MeSH), Influenza, Human (drug therapy), Influenza, Human (epidemiology), Influenza, Human (therapy), Male (MeSH), Oseltamivir (therapeutic use), Oxygen Inhalation Therapy (statistics & numerical data), Pandemics (MeSH), Risk Factors (MeSH), Seasons (MeSH), Spain (epidemiology).
- MESH :
- chemical , therapeutic use : Anti-Bacterial Agents, Antiviral Agents, Oseltamivir.
- drug therapy : Influenza, Human.
- epidemiology : Influenza, Human, Spain.
- statistics & numerical data : Critical Care, Hospitalization, Oxygen Inhalation Therapy.
- therapy : Influenza, Human.
- Adolescent, Age of Onset, Child, Child, Preschool, Combined Modality Therapy, Comorbidity, Female, Humans, Infant, Infant, Newborn, Influenza A Virus, H1N1 Subtype, Male, Pandemics, Risk Factors, Seasons.
Abstract
INTRODUCTION
Most of the published studies on patients admitted with 2009 pandemic influenza are not population based. We have compiled the clinical information regarding all children admitted with 2009 pandemic influenza A (H1N1) infection during the season 2009-2010 in our defined population, in order to have an unbiased view of the most severe side of the clinical spectrum of the infection and to quantify its burden.
METHODS
Children <15 years-old admitted to any of 3 hospitals in South-East Spain with 2009 pandemic influenza A (H1N1) detected by means of reverse transcriptase polymerase chain reaction. High quality data were extracted from clinical records specially designed for the pandemic.
RESULTS
Eighty two children fulfilled the inclusion criteria. The hospitalization rate was 68 per 100,000 children <15 years-old; in those <5 years-old the rate was of 131 and in <1 year-old, 234 per 100,000. An estimated 0.7% of the children who suffered from pandemic influenza were admitted (1.7% in <5 years-old). Intensive care was required for 5% of the hospitalized patients living in the study area. Mortality was roughly estimated about 1 per 100,000 children <15 years-old and was associated with the presence of very severe comorbidities or co-infections. Only 20% of the admitted children were ≥ 5 years-old and without risk factors. The disease followed a generally benign course despite the modest use of oseltamivir (49% of the patients).
CONCLUSIONS
Clinical and epidemiological data are very similar to those observed in other places and in interpandemic seasons with a high influenza activity.
DOI: 10.1016/j.eimc.2011.01.015
PubMed: 21514011
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<term>Infant, Newborn (MeSH)</term>
<term>Influenza A Virus, H1N1 Subtype (MeSH)</term>
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<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (therapy)</term>
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<front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b>
</p>
<p>Most of the published studies on patients admitted with 2009 pandemic influenza are not population based. We have compiled the clinical information regarding all children admitted with 2009 pandemic influenza A (H1N1) infection during the season 2009-2010 in our defined population, in order to have an unbiased view of the most severe side of the clinical spectrum of the infection and to quantify its burden.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Children <15 years-old admitted to any of 3 hospitals in South-East Spain with 2009 pandemic influenza A (H1N1) detected by means of reverse transcriptase polymerase chain reaction. High quality data were extracted from clinical records specially designed for the pandemic.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Eighty two children fulfilled the inclusion criteria. The hospitalization rate was 68 per 100,000 children <15 years-old; in those <5 years-old the rate was of 131 and in <1 year-old, 234 per 100,000. An estimated 0.7% of the children who suffered from pandemic influenza were admitted (1.7% in <5 years-old). Intensive care was required for 5% of the hospitalized patients living in the study area. Mortality was roughly estimated about 1 per 100,000 children <15 years-old and was associated with the presence of very severe comorbidities or co-infections. Only 20% of the admitted children were ≥ 5 years-old and without risk factors. The disease followed a generally benign course despite the modest use of oseltamivir (49% of the patients).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Clinical and epidemiological data are very similar to those observed in other places and in interpandemic seasons with a high influenza activity.</p>
</div>
</front>
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<Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Most of the published studies on patients admitted with 2009 pandemic influenza are not population based. We have compiled the clinical information regarding all children admitted with 2009 pandemic influenza A (H1N1) infection during the season 2009-2010 in our defined population, in order to have an unbiased view of the most severe side of the clinical spectrum of the infection and to quantify its burden.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Children <15 years-old admitted to any of 3 hospitals in South-East Spain with 2009 pandemic influenza A (H1N1) detected by means of reverse transcriptase polymerase chain reaction. High quality data were extracted from clinical records specially designed for the pandemic.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Eighty two children fulfilled the inclusion criteria. The hospitalization rate was 68 per 100,000 children <15 years-old; in those <5 years-old the rate was of 131 and in <1 year-old, 234 per 100,000. An estimated 0.7% of the children who suffered from pandemic influenza were admitted (1.7% in <5 years-old). Intensive care was required for 5% of the hospitalized patients living in the study area. Mortality was roughly estimated about 1 per 100,000 children <15 years-old and was associated with the presence of very severe comorbidities or co-infections. Only 20% of the admitted children were ≥ 5 years-old and without risk factors. The disease followed a generally benign course despite the modest use of oseltamivir (49% of the patients).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Clinical and epidemiological data are very similar to those observed in other places and in interpandemic seasons with a high influenza activity.</AbstractText>
<CopyrightInformation>Copyright © 2010 Elsevier España, S.L. All rights reserved.</CopyrightInformation>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Moral</LastName>
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<ForeName>Teresa</ForeName>
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<Author ValidYN="Y"><LastName>Fuentes</LastName>
<ForeName>María Jesús</ForeName>
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<Author ValidYN="Y"><LastName>Fuentes</LastName>
<ForeName>Laura</ForeName>
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<Author ValidYN="Y"><LastName>Lillo</LastName>
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<tree><noCountry><name sortKey="Fuentes, Laura" sort="Fuentes, Laura" uniqKey="Fuentes L" first="Laura" last="Fuentes">Laura Fuentes</name>
<name sortKey="Fuentes, Maria Jesus" sort="Fuentes, Maria Jesus" uniqKey="Fuentes M" first="María Jesús" last="Fuentes">María Jesús Fuentes</name>
<name sortKey="Lillo, Lucia" sort="Lillo, Lucia" uniqKey="Lillo L" first="Lucía" last="Lillo">Lucía Lillo</name>
<name sortKey="Marco, Nuria" sort="Marco, Nuria" uniqKey="Marco N" first="Nuria" last="Marco">Nuria Marco</name>
<name sortKey="Toral, Teresa" sort="Toral, Teresa" uniqKey="Toral T" first="Teresa" last="Toral">Teresa Toral</name>
</noCountry>
<country name="Espagne"><noRegion><name sortKey="Moral, Luis" sort="Moral, Luis" uniqKey="Moral L" first="Luis" last="Moral">Luis Moral</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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